This is the manuscript of Holmes' thesis, submitted as part of the degree requirements at Harvard Medical School. Following his return from his sojourn in Europe, he compiled the thesis from lectures of Pierre Charles Alexandre Louis he had attended and cases seen at La Pitié, but "rapidly, for circumstances obliged me to prepare it entirely in the space of little more than three days; imperfectly, for I had only the resources of my own library and notes, and had scarcely time to analyse any cases besides those I had reduced to the tabular form two years before." Title page and first page of Olver Wendell Holmes's (1809-1894) thesis, A dissertation on acute pericarditis
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